Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.48 |
| ▸ | DCK | P27707 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2060253 | 0.93 | RIPK1 (0.48) | RIPK1DCKGRM5ALDH1A1LMNA | |
| SCHEMBL885846 | 0.92 | KDR (0.41) | RIPK1DCKGRM5ALDH1A1LMNA | |
| SCHEMBL2060124 | 0.92 | RIPK1 (0.47) | RIPK1GRM5SMN1; SMN2MCHR1 | |
| SCHEMBL2060043 | 0.86 | RIPK1 (0.52) | RIPK1DCKGRM5SMN1; SMN2SMYD3 | |
| SCHEMBL885848 | 0.83 | RIPK1 (0.47) | RIPK1DCKGRM5CCNB2CDK1 | |
| SCHEMBL885700 | 0.82 | RIPK1 (0.53) | RIPK1GRM5SMYD3KITMCHR1 | |
| SCHEMBL885793 | 0.79 | RIPK1 (0.42) | RIPK1GRM5SMN1; SMN2MCHR1HPGDS | |
| SCHEMBL885593 | 0.76 | MCHR1 (0.45) | RIPK1GRM5SMN1; SMN2SMYD3MCHR1 | |
| SCHEMBL885585 | 0.75 | RIPK1 (0.45) | RIPK1KITMCHR1ULK1 | |
| SCHEMBL2060255 | 0.74 | RIPK1 (0.47) | RIPK1DCKSMYD3MCHR1HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081928-A2 | PYRROLO-PYRIDINE KINASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-07-29 | — | — | EP | claimed |
| WO-2008060907-A2 | PYRROLO-PYRIDINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-22 | — | — | WO | claimed |