Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | DCK | P27707 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885846 | 0.93 | KDR (0.41) | RIPK1KDRMAPK14MCHR1DCK | |
| SCHEMBL2060255 | 0.93 | RIPK1 (0.47) | RIPK1KDRMAPK14MCHR1DCK | |
| SCHEMBL2060127 | 0.91 | KDR (0.54) | RIPK1KDRMAPK14MCHR1DRD4 | |
| SCHEMBL2060044 | 0.86 | RIPK1 (0.51) | RIPK1KDRMAPK14MCHR1SMYD3 | |
| SCHEMBL885847 | 0.83 | RIPK1 (0.48) | RIPK1MCHR1DCKSMYD3CCNB2 | |
| SCHEMBL885701 | 0.81 | RIPK1 (0.52) | RIPK1KDRMAPK14SMYD3DRD4 | |
| SCHEMBL885792 | 0.78 | HDAC1 (0.43) | RIPK1KDRMAPK14MCHR1HDAC1 | |
| SCHEMBL885592 | 0.75 | KDR (0.48) | RIPK1KDRMAPK14MCHR1SMYD3 | |
| SCHEMBL885586 | 0.75 | KIT (0.50) | RIPK1KDRHDAC1HDAC8HDAC6 | |
| SCHEMBL2060253 | 0.75 | RIPK1 (0.48) | RIPK1MAPK14MCHR1DCKSMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081928-A2 | PYRROLO-PYRIDINE KINASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-07-29 | — | — | EP | claimed |
| WO-2008060907-A2 | PYRROLO-PYRIDINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-22 | — | — | WO | claimed |