SCHEMBL8858591

SCHEMBL8858591

CCNCCc1cccc2ccccc12

nearest known ligand 0.58

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 1/20 0.58
HPGD P15428 1/20 0.57
MTNR1A P48039 2/20 0.55
HTR1B P28222 1/20 0.54
HTR2A P28223 1/20 0.54
CYP1A2 P05177 2/20 0.47
CYP2C19 P33261 2/20 0.47
CYP2D6 P10635 1/20 0.47
SMPD1 P17405 1/20 0.47
SIGMAR1 Q99720 1/20 0.47
CYP2C9 P11712 1/20 0.46
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA4 P22748 1/20 0.44
CA9 Q16790 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8794788 0.88 HPGD (0.64) NQO2HPGDMTNR1ACYP1A2CYP2C19
SCHEMBL66918 0.82 CYP1A2 (0.55) NQO2MTNR1ACYP1A2CYP2C19CYP2D6
SCHEMBL4802023 0.82 SIGMAR1 (0.54) NQO2HPGDMTNR1ASIGMAR1CA12
SCHEMBL606293 0.81 MTNR1A (0.63) NQO2HPGDMTNR1AHTR1BHTR2A
SCHEMBL3626833 0.81 MC5R (0.57) HPGDHTR1BCYP1A2CYP2C19CYP2D6
SCHEMBL9014734 0.80 CYP1A2 (0.53) NQO2MTNR1ACYP1A2CYP2C19CYP2D6
SCHEMBL10624208 0.80 CYP1A2 (0.53) NQO2MTNR1ACYP1A2CYP2C19CYP2D6
Phosphine SCHEMBL28240997 0.80 CYP1A2 (0.53) NQO2MTNR1ACYP1A2CYP2C19CYP2D6
SCHEMBL10624219 0.80 CYP1A2 (0.53) NQO2MTNR1ACYP1A2CYP2C19CYP2D6
SCHEMBL28302188 0.80 CYP1A2 (0.53) NQO2MTNR1ACYP1A2CYP2C19CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012127385-A1 BENZO [B] [1, 4] OXAZIN DERIVATIVES AS CALCIUM SENSING RECEPTOR MODULATORS LUPIN LIMITED (IN) 2012-09-27 WO disclosed
US-5616614-A USEFUL IN TREATMENT OF DISORDERS LINKED TO ABNORMAL MELATONIN ACTIVITY ADIR ET COMPAGNIE (FR) 1997-04-01 US disclosed
US-5420158-A Melatonin activity ADIR ET COMPAGNIE (FR) 1995-05-30 US disclosed