Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GCK | P35557 | 12/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8858785 | 0.94 | HDAC4 (0.49) | GRAMD1AHDAC4NPC1RAB9AHDAC6 | |
| SCHEMBL8858733 | 0.93 | GRAMD1A (0.51) | GRAMD1AHDAC4NPC1RAB9AHDAC6 | |
| SCHEMBL8858700 | 0.89 | GRAMD1A (0.47) | GRAMD1AHDAC4KDM4EMAPTGCK | |
| SCHEMBL8858740 | 0.87 | HDAC4 (0.49) | GRAMD1AHDAC4NPC1RAB9AHDAC6 | |
| SCHEMBL8858634 | 0.85 | USP30 (0.49) | GRAMD1AHDAC4NPC1RAB9AKDM4E | |
| SCHEMBL8858804 | 0.82 | HDAC4 (0.42) | HDAC4NPC1RAB9AHDAC6KDM4E | |
| SCHEMBL8858824 | 0.82 | GRAMD1A (0.47) | GRAMD1AHDAC4NPC1RAB9AKDM4E | |
| SCHEMBL8858696 | 0.81 | GRAMD1A (0.55) | GRAMD1ANPC1RAB9AKDM4EMAPT | |
| SCHEMBL3666966 | 0.79 | NPC1 (0.54) | GRAMD1ANPC1RAB9AKDM4EMAPT | |
| SCHEMBL20792856 | 0.78 | DPP4 (0.53) | GRAMD1ANPC1RAB9AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607944-A | ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-03-04 | — | — | US | disclosed |
| EP-0639575-A1 | Bicyclic heterocycles, medicaments comprising these compounds and processes for their production | Dr. Karl Thomae GmbH (DE) | 1995-02-22 | — | — | EP | disclosed |