Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8858733 | 0.94 | GRAMD1A (0.51) | HDAC4HDAC6GRAMD1ANPC1RAB9A | |
| SCHEMBL8858785 | 0.93 | HDAC4 (0.49) | HDAC4HDAC6GRAMD1APOLBNPC1 | |
| SCHEMBL8858682 | 0.87 | GRAMD1A (0.51) | HDAC4HDAC6GRAMD1ANPC1RAB9A | |
| SCHEMBL8858794 | 0.86 | HDAC4 (0.43) | HDAC4HDAC6NPC1RAB9AKMT2A | |
| SCHEMBL8858634 | 0.84 | USP30 (0.49) | HDAC4GRAMD1APOLBNPC1RAB9A | |
| SCHEMBL8858824 | 0.83 | GRAMD1A (0.47) | HDAC4GRAMD1ANPC1RAB9AGPR119 | |
| SCHEMBL8858771 | 0.82 | NPC1 (0.47) | HDAC4GRAMD1ANPC1RAB9AGPR119 | |
| SCHEMBL8858804 | 0.79 | HDAC4 (0.42) | HDAC4HDAC6NPC1RAB9AKMT2A | |
| SCHEMBL8858775 | 0.78 | MEN1 (0.43) | HDAC4HDAC6NPC1RAB9AKMT2A | |
| SCHEMBL8858741 | 0.78 | SCN4A (0.41) | GRAMD1APOLBPTPN2PTPN1PTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607944-A | ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-03-04 | — | — | US | disclosed |
| EP-0639575-A1 | Bicyclic heterocycles, medicaments comprising these compounds and processes for their production | Dr. Karl Thomae GmbH (DE) | 1995-02-22 | — | — | EP | disclosed |