Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | PKM | P14618 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.70 |
| ▸ | RELA | Q04206 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | RHEB | Q15382 | 1/20 | 0.62 |
| ▸ | MMP2 | P08253 | 1/20 | 0.60 |
| ▸ | MMP9 | P14780 | 1/20 | 0.60 |
| ▸ | MMP8 | P22894 | 1/20 | 0.60 |
| ▸ | MMP13 | P45452 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14605796 | 0.99 | KDM4E (0.68) | KDM4EALDH1A1HPGDNPC1LMNA | |
| SCHEMBL14605798 | 0.87 | KDM4E (0.57) | KDM4EALDH1A1HPGDNPC1LMNA | |
| SCHEMBL8858540 | 0.83 | ALDH1A1 (0.65) | KDM4EALDH1A1HPGDNPC1PKM | |
| SCHEMBL14605976 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1HPGDNPC1LMNA | |
| SCHEMBL25318263 | 0.82 | KDM4E (0.75) | KDM4EALDH1A1HPGDNPC1LMNA | |
| SCHEMBL20982713 | 0.82 | KDM4E (0.75) | KDM4EALDH1A1HPGDNPC1LMNA | |
| SCHEMBL29906102 | 0.82 | KDM4E (0.75) | KDM4EALDH1A1HPGDNPC1LMNA | |
| SCHEMBL2617471 | 0.82 | NPC1 (1.00) | KDM4EALDH1A1HPGDNPC1LMNA | |
| SCHEMBL6264454 | 0.82 | PKN1 (0.63) | HPSEPKN1PKN2 | |
| SCHEMBL14605760 | 0.82 | ALDH1A1 (0.63) | KDM4EALDH1A1HPGDNPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607944-A | ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-03-04 | — | — | US | disclosed |
| EP-0639575-A1 | Bicyclic heterocycles, medicaments comprising these compounds and processes for their production | Dr. Karl Thomae GmbH (DE) | 1995-02-22 | — | — | EP | disclosed |