Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.50 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | BHMT | Q93088 | 3/20 | 0.38 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.35 |
| ▸ | ARG1 | P05089 | 3/20 | 0.34 |
| ▸ | ARG2 | P78540 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8860269 | 1.00 | GSR (0.50) | GSRSLC7A5SLC1A2SLC1A3BHMT | |
| Lysine SCHEMBL8679690 | 0.94 | GSR (0.57) | GSRBHMTBHMT2NOS3NOS1 | |
| Lysine SCHEMBL8679695 | 0.94 | GSR (0.57) | GSRBHMTBHMT2NOS3NOS1 | |
| Lysine SCHEMBL8836633 | 0.92 | GSR (0.59) | GSRSLC7A5SLC1A2SLC1A3BHMT | |
| Lysine SCHEMBL8836635 | 0.92 | GSR (0.59) | GSRSLC7A5SLC1A2SLC1A3BHMT | |
| Lysine SCHEMBL23088726 | 0.91 | GSR (0.61) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 | |
| Leucine SCHEMBL27487105 | 0.91 | SLC7A5 (0.55) | SLC7A5SLC1A2SLC1A3BHMTBHMT2 | |
| Leucine SCHEMBL27814601 | 0.91 | SLC7A5 (0.55) | SLC7A5SLC1A2SLC1A3BHMTBHMT2 | |
| Lysine SCHEMBL3854800 | 0.91 | GSR (0.61) | GSRSLC7A5SLC1A2SLC1A3SLC1A1 | |
| Lysine SCHEMBL16876651 | 0.90 | GSR (0.53) | GSRBHMTBHMT2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597945-A | Plants genetically enhanced for disease resistance | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 1997-01-28 | — | — | US | disclosed |