Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.57 |
| ▸ | BHMT | Q93088 | 4/20 | 0.42 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 5/20 | 0.39 |
| ▸ | NOS1 | P29475 | 4/20 | 0.39 |
| ▸ | NOS3 | P29474 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | ARG2 | P78540 | 4/20 | 0.38 |
| ▸ | ARG1 | P05089 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8679695 | 1.00 | GSR (0.57) | GSRBHMTBHMT2NOS2NOS1 | |
| Lysine SCHEMBL16876651 | 0.96 | GSR (0.53) | GSRBHMTBHMT2NOS2NOS1 | |
| Lysine SCHEMBL16876653 | 0.96 | GSR (0.53) | GSRBHMTBHMT2NOS2NOS1 | |
| Racemethionine SCHEMBL15322970 | 0.94 | GSR (0.49) | GSRBHMTBHMT2NOS2NOS1 | |
| Methionine SCHEMBL15322975 | 0.94 | GSR (0.49) | GSRBHMTBHMT2NOS2NOS1 | |
| Lysine SCHEMBL8860269 | 0.94 | GSR (0.50) | GSRBHMTBHMT2NOS2NOS1 | |
| Lysine SCHEMBL8860263 | 0.94 | GSR (0.50) | GSRBHMTBHMT2NOS2NOS1 | |
| Lysine SCHEMBL8676174 | 0.92 | GSR (0.49) | GSRBHMTBHMT2NOS2NOS1 | |
| Lysine SCHEMBL8676173 | 0.92 | GSR (0.49) | GSRBHMTBHMT2NOS2NOS1 | |
| Racemethionine SCHEMBL15323591 | 0.91 | GSR (0.45) | GSRBHMTBHMT2NOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811654-A | LIMITING AMINO ACIDS OF POLYPEPTIDE ARE SELECTED FROM LYSINE, TRYPTOPHAN, METHIONINE, THREONINE AND ISOLEUCINE | LOUISIANA STATE UNIVERSITY (US) | 1998-09-22 | — | — | US | disclosed |
| US-5597945-A | Plants genetically enhanced for disease resistance | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 1997-01-28 | — | — | US | disclosed |