Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8861849 | 0.94 | HRH2 (0.46) | HRH2POLBLMNACYP2D6CYP2C19 | |
| SCHEMBL9047699 | 0.79 | LMNA (0.48) | POLBLMNAALDH1A1MAPTDRD2 | |
| SCHEMBL14528083 | 0.69 | HRH2 (0.66) | HRH2POLBLMNAACHEMAPT | |
| SCHEMBL5692251 | 0.69 | HRH2 (0.66) | HRH2POLBLMNAACHEMAPT | |
| SCHEMBL20284487 | 0.69 | HRH2 (0.66) | HRH2POLBLMNAACHEMAPT | |
| SCHEMBL9039441 | 0.68 | LMNA (0.52) | POLBLMNAMAPK1ALDH1A1DRD2 | |
| SCHEMBL8861842 | 0.64 | SIGMAR1 (0.53) | POLBLMNAALDH1A1MAPTCYP2D6 | |
| SCHEMBL20432883 | 0.64 | LMNA (0.71) | POLBLMNAMAPK1BCHEACHE | |
| SCHEMBL20432817 | 0.63 | KDM4E (0.43) | HRH2POLBLMNAMAPK1ALDH1A1 | |
| SCHEMBL13554190 | 0.62 | HRH2 (0.56) | HRH2ACHEALDH1A1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684006-A | Isoxazole and pyrazole derivatives as dopamine receptor subtype ligands | MERCK, SHARP & DOHME, LTD. (GB) | 1997-11-04 | — | — | US | disclosed |