Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.70 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.68 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.68 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.62 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.59 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6011697 | 0.86 | CYP4F2 (0.73) | LOXL2CYP4F2CYP4A11FOLH1SLC7A5 | |
| SCHEMBL70173 | 0.85 | CYP4F2 (0.83) | LOXL2CYP4F2CYP4A11FOLH1SLC7A5 | |
| SCHEMBL126284 | 0.85 | LOXL2 (0.74) | LOXL2CYP4F2CYP4A11FOLH1SLC7A5 | |
| SCHEMBL40012 | 0.84 | CYP4F2 (0.75) | LOXL2CYP4F2CYP4A11FOLH1SLC7A5 | |
| SCHEMBL31276630 | 0.84 | CYP4F2 (0.75) | LOXL2CYP4F2CYP4A11FOLH1SLC7A5 | |
| SCHEMBL30230926 | 0.84 | LOXL2 (0.72) | LOXL2CYP4F2CYP4A11FOLH1SLC7A5 | |
| SCHEMBL95887 | 0.84 | LOXL2 (0.72) | LOXL2CYP4F2CYP4A11FOLH1SLC7A5 | |
| SCHEMBL8921794 | 0.83 | CYP4A11 (0.73) | LOXL2CYP4F2CYP4A11FOLH1SLC7A5 | |
| SCHEMBL5564526 | 0.82 | LOXL2 (0.70) | LOXL2CYP4F2CYP4A11FOLH1SLC7A5 | |
| SCHEMBL6032783 | 0.82 | LOXL2 (0.70) | LOXL2CYP4F2CYP4A11FOLH1SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656636-A | TREATING PSORIASIS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-12 | — | — | US | disclosed |
| US-5633258-A | Pyridine compounds for treating leukotriene-related diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-27 | — | — | US | disclosed |
| US-5631262-A | Pyridine compounds for treating leukotriene-related diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-20 | — | — | US | disclosed |
| EP-0604529-A1 | PYRIDINE COMPOUNDS FOR TREATING LEUKOTRIENE-RELATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-06 | — | — | EP | disclosed |
| WO-1993006085-A1 | PYRIDINE COMPOUNDS FOR TREATING LEUKOTRIENE-RELATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-01 | — | — | WO | disclosed |
| EP-0123543-B1 | LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION AND USE AND COMPOSITIONS CONTAINING THEM | MERCK FROSST CANADA INC. (CA) | 1988-02-03 | — | — | EP | disclosed |
| US-4609744-A | 4-oxo-benzopyran carboxylic acids | MERCK FROSST CANADA INC. (CA) | 1986-09-02 | — | — | US | disclosed |
| EP-0123543-A1 | Leukotriene antagonists, their production and use and compositions containing them | MERCK FROSST CANADA INC. (CA) | 1984-10-31 | — | — | EP | disclosed |