Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 6/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8862061 | 1.00 | LTB4R (0.47) | LTB4RCNR1CNR2PDE5AALDH1A1 | |
| SCHEMBL8862053 | 0.85 | LTB4R (0.53) | LTB4RCNR1CNR2ALDH1A1HPGD | |
| SCHEMBL8862049 | 0.85 | LTB4R (0.53) | LTB4RCNR1CNR2ALDH1A1HPGD | |
| SCHEMBL27447110 | 0.84 | LTB4R (0.52) | LTB4RCNR1CNR2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL8862113 | 0.83 | LTB4R (0.51) | LTB4RCNR1CNR2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL8862116 | 0.83 | LTB4R (0.51) | LTB4RCNR1CNR2ALDH1A1HPGD | |
| SCHEMBL8862019 | 0.82 | LTB4R (0.55) | LTB4R | |
| SCHEMBL8862022 | 0.82 | LTB4R (0.55) | LTB4R | |
| SCHEMBL9489703 | 0.81 | PTPN1 (0.47) | LTB4RPDE5APTPN1 | |
| SCHEMBL9489690 | 0.81 | PTPN1 (0.47) | LTB4RPDE5APTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656636-A | TREATING PSORIASIS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-12 | — | — | US | disclosed |
| US-5633258-A | Pyridine compounds for treating leukotriene-related diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-27 | — | — | US | disclosed |
| US-5631262-A | Pyridine compounds for treating leukotriene-related diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-20 | — | — | US | disclosed |
| EP-0604529-A1 | PYRIDINE COMPOUNDS FOR TREATING LEUKOTRIENE-RELATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-06 | — | — | EP | disclosed |
| EP-0593464-A1 | BENZOIC ACID DERIVATIVES and their use as LTB4 inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1994-04-27 | — | — | EP | disclosed |
| WO-1993006085-A1 | PYRIDINE COMPOUNDS FOR TREATING LEUKOTRIENE-RELATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-01 | — | — | WO | disclosed |
| EP-0593464-A4 | BENZOIC ACID DERIVATIVES. | SMITHKLINE BEECHAM CORP (US) | 1993-02-12 | — | — | EP | disclosed |
| WO-1991018601-A1 | BENZOIC ACID DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 1991-12-12 | — | — | WO | disclosed |