Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.44 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9491626 | 1.00 | PTPN1 (0.47) | PTPN1LMNAMEN1NR1I2CHRM2 | |
| SCHEMBL27342509 | 1.00 | PTPN1 (0.47) | PTPN1LMNAMEN1NR1I2CHRM2 | |
| SCHEMBL9490927 | 1.00 | PTPN1 (0.47) | PTPN1LMNAMEN1NR1I2CHRM2 | |
| SCHEMBL9490917 | 1.00 | PTPN1 (0.47) | PTPN1LMNAMEN1NR1I2CHRM2 | |
| SCHEMBL9491635 | 1.00 | PTPN1 (0.47) | PTPN1LMNAMEN1NR1I2CHRM2 | |
| SCHEMBL9489703 | 1.00 | PTPN1 (0.47) | PTPN1LMNAMEN1NR1I2CHRM2 | |
| SCHEMBL9545803 | 0.82 | LTB4R (0.52) | LTB4R | |
| SCHEMBL8862066 | 0.81 | LTB4R (0.47) | PTPN1LTB4RPDE5A | |
| SCHEMBL8862061 | 0.81 | LTB4R (0.47) | PTPN1LTB4RPDE5A | |
| SCHEMBL9490819 | 0.79 | PTPN1 (0.48) | PTPN1LMNAMEN1NR1I2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532621-A1 | AMIDE LINKED PYRIDYLE-BENZOIC ACID DERIVATIVES FOR TREATING LEUKOTRIENE-RELATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| CN-1057834-A | Be used for the treatment of the pyridine-benzoic acid derivative that is connected with the acid amides of leukotriene-related disease | SMITHLINE BEECHAN CORP (US) | 1992-01-15 | — | — | CN | disclosed |
| WO-1991018883-A1 | AMIDE LINKED PYRIDYLE-BENZOIC ACID DERIVATIVES FOR TREATING LEUKOTRIENE-RELATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1991-12-12 | — | — | WO | disclosed |