Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.59 |
| ▸ | ECE1 | P42892 | 4/20 | 0.58 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | IL1RN | P18510 | 1/20 | 0.56 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.56 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.56 |
| ▸ | MME | P08473 | 1/20 | 0.55 |
| ▸ | NMBR | P28336 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8862510 | 1.00 | ACE (0.59) | ACEECE1LTA4HIL1RNERAP2 | |
| SCHEMBL27455388 | 1.00 | ACE (0.59) | ACEECE1LTA4HIL1RNERAP2 | |
| SCHEMBL5379545 | 0.89 | ALOX15 (0.59) | ACEECE1LTA4HNMBRMMP2 | |
| SCHEMBL5379543 | 0.89 | ALOX15 (0.59) | ACEECE1LTA4HNMBRMMP2 | |
| SCHEMBL14595066 | 0.81 | NMBR (0.76) | ACEECE1MMENMBR | |
| SCHEMBL30311024 | 0.80 | ACE (0.70) | ACEECE1 | |
| SCHEMBL29384133 | 0.80 | KDM4E (0.65) | ACEECE1ERAP2 | |
| SCHEMBL31326046 | 0.80 | NMBR (0.74) | ACEECE1LTA4HMMENMBR | |
| SCHEMBL5583835 | 0.79 | KDM4E (0.68) | ACEECE1ERAP2 | |
| SCHEMBL21641803 | 0.79 | KDM4E (0.68) | ACEECE1ERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607934-A | PREVENTING AND TREATING DISEASES CAUSED BY SUPEROXIDE RADICALS, NEPHRITIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0659182-A1 | PIPERAZINE DERIVATIVES AND SALTS THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-06-28 | — | — | EP | disclosed |
| WO-1995002593-A1 | PIPERAZINE DERIVATIVES AND SALTS THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-01-26 | — | — | WO | disclosed |