Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 7/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | GLS | O94925 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8863514 | 1.00 | ALDH1A1 (0.41) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL8863509 | 1.00 | ALDH1A1 (0.41) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL17078163 | 0.93 | RIPK1 (0.39) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL16439471 | 0.93 | RIPK1 (0.39) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL17078162 | 0.93 | RIPK1 (0.39) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL17800375 | 0.93 | RIPK1 (0.39) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL17086509 | 0.89 | SMN1; SMN2 (0.37) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL18603657 | 0.89 | SMN1; SMN2 (0.37) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL18603655 | 0.89 | SMN1; SMN2 (0.37) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL18603429 | 0.86 | ALDH1A1 (0.37) | ALDH1A1GAAHTTNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668164-A | Process for synthesis of chiral cis-and trans-3-amino-4 substituted pyrrolidine compounds | ABBOTT LABORATORIES (US) | 1997-09-16 | — | — | US | disclosed |
| US-5618949-A | Process for synthesis of chiral cis- and trans-3-amino-4-substituted pyrrolidine compounds | ABBOTT LABORATORIES (US) | 1997-04-08 | — | — | US | disclosed |