SCHEMBL8863992

SCHEMBL8863992

Cc1ccc(S(=O)(=O)OCC2CCc3cc(F)ccc3O2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.47
CYP2D6 P10635 3/20 0.41
ALDH1A1 P00352 2/20 0.41
CYP3A4 P08684 2/20 0.41
TSHR P16473 2/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
MAPT P10636 1/20 0.41
MAPK1 P28482 1/20 0.41
HTR1A P08908 2/20 0.40
MLNR O43193 1/20 0.40
ADRB2 P07550 1/20 0.40
ADRB1 P08588 1/20 0.40
ADRA2A P08913 1/20 0.40
ADORA3 P0DMS8 1/20 0.40
CHRM1 P11229 1/20 0.40
DRD2 P14416 1/20 0.40
KCNE1 P15382 1/20 0.40
ADRA2B P18089 1/20 0.40
ADRA2C P18825 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1043201 0.91 CA2 (0.47) CA2CYP2D6ALDH1A1CYP3A4TSHR
SCHEMBL13230301 0.90 CA2 (0.51) CA2CYP2D6ALDH1A1CYP3A4TSHR
SCHEMBL9370374 0.89 MAOB (0.39) CA2CYP2D6ALDH1A1CYP3A4TSHR
SCHEMBL6348557 0.83 CA2 (0.68) CA2CYP2D6ALDH1A1CYP3A4TSHR
SCHEMBL4970970 0.83 CA2 (0.68) CA2CYP2D6ALDH1A1CYP3A4TSHR
SCHEMBL7346088 0.83 CA2 (0.68) CA2CYP2D6ALDH1A1CYP3A4TSHR
SCHEMBL8863996 0.82 HTR1A (0.44) CYP2D6HTR1AMLNRADRB2ADRB1
SCHEMBL1872709 0.81 CA2 (0.47) CA2CYP2D6ALDH1A1CYP3A4TSHR
SCHEMBL9369808 0.81 CA2 (0.53) CA2CYP2D6ALDH1A1CYP3A4TSHR
SCHEMBL1043747 0.81 CA2 (0.47) CA2CYP2D6ALDH1A1CYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5703115-A VASOCONSTRICTORS JANSSEN PHARMACEUTICA, N.V. (BE) 1997-12-30 US disclosed
US-5688952-A VASOCONSTRICTOR INTERMEDIATES JANSSEN PHARMACEUTICA, N.V. (BE) 1997-11-18 US disclosed
US-5624952-A VASOCONSTRICTORS JANSSEN PHARMACEUTICA N.V. (BE) 1997-04-29 US disclosed
US-5607949-A VASOCONTRICTORS, TREATING MIGRAIN JANSSEN PHARMACEUTICA N.V. (BE) 1997-03-04 US disclosed
US-5541180-A HEADACHE THERAPY JANSSEN PHARMACEUTICA N.V. (BE) 1996-07-30 US disclosed
EP-0639192-A1 (BENZODIOXAN, BENZOFURAN OR BENZOPYRAN)-ALKYLAMINO] ALKYL SUBSTITUTED GUANIDINES AS SELECTIVE VASCOCONSTRICTORS. JANSSEN PHARMACEUTICA NV (BE) 1995-02-22 EP disclosed
WO-1993017017-A1 [(BENZODIOXAN, BENZOFURAN OR BENZOPYRAN)-ALKYLAMINO] ALKYL SUBSTITUTED GUANIDINES AS SELECTIVE VASCOCONSTRICTORS JANSSEN PHARMACEUTICA N.V. (BE) 1993-09-02 WO disclosed