Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 16/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 16/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 15/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8865110 | 0.71 | SLC6A2 (0.52) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8864666 | 0.71 | KCNH2 (0.55) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL8864617 | 0.69 | KCNH2 (0.52) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9257287 | 0.63 | MEN1 (0.37) | SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8556675 | 0.60 | MAOA (0.42) | KCNH2CYP2D6SMN1; SMN2 | |
| SCHEMBL12539165 | 0.60 | PLG (0.41) | PTGS2 | |
| SCHEMBL8558645 | 0.59 | KCNH2 (0.72) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL8555627 | 0.59 | KCNH2 (0.72) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 | |
| Hydrochloric Acid SCHEMBL8557094 | 0.59 | KCNH2 (0.60) | KCNH2SLC6A2SLC6A4SLC6A3PTGS2 | |
| SCHEMBL8557530 | 0.59 | KCNH2 (0.72) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624922-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0597540-B1 | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC (US) | 1996-06-05 | — | — | EP | disclosed |
| US-5380721-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0597540-A1 | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1994-05-18 | — | — | EP | disclosed |