Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.97 |
| ▸ | TSHR | P16473 | 3/20 | 0.83 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.83 |
| ▸ | USP2 | O75604 | 2/20 | 0.83 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565487 | 0.99 | SMN1; SMN2 (1.00) | SMN1; SMN2TSHRNPSR1USP2POLB | |
| Bromide SCHEMBL8864504 | 0.93 | SMN1; SMN2 (0.84) | SMN1; SMN2TSHRNPSR1USP2POLB | |
| SCHEMBL9568271 | 0.91 | SMN1; SMN2 (0.86) | SMN1; SMN2TSHRNPSR1USP2POLB | |
| SCHEMBL8563635 | 0.88 | SMN1; SMN2 (0.80) | SMN1; SMN2TSHRNPSR1USP2POLB | |
| Hydrochloric Acid SCHEMBL8864540 | 0.86 | SMN1; SMN2 (0.78) | SMN1; SMN2TSHRNPSR1USP2POLB | |
| SCHEMBL29738297 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2TSHRNPSR1USP2ALDH1A1 | |
| Bromide SCHEMBL1294356 | 0.82 | SMN1; SMN2 (0.68) | SMN1; SMN2TSHRNPSR1USP2POLB | |
| SCHEMBL6325602 | 0.82 | SMN1; SMN2 (0.70) | SMN1; SMN2TSHRNPSR1USP2POLB | |
| Bromide SCHEMBL8864430 | 0.81 | TSHR (0.67) | SMN1; SMN2TSHRNPSR1USP2POLB | |
| SCHEMBL6321352 | 0.81 | NPSR1 (0.98) | SMN1; SMN2TSHRNPSR1USP2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639756-A | ANTIDIABETIC AGENTS | ADIR ET COMPAGNIE (FR) | 1997-06-17 | — | — | US | disclosed |
| US-5623073-A | ANTIDIABETIC AGENT | ADIR ET COMPAGNIE (FR) | 1997-04-22 | — | — | US | disclosed |