Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | CTSD | P07339 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565487 | 0.83 | SMN1; SMN2 (1.00) | SMN1; SMN2TSHRMEN1KMT2ANPSR1 | |
| Bromide SCHEMBL8864660 | 0.82 | SMN1; SMN2 (0.97) | SMN1; SMN2TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL8563635 | 0.82 | SMN1; SMN2 (0.80) | SMN1; SMN2TSHRCYP1A2CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL8864540 | 0.81 | SMN1; SMN2 (0.78) | SMN1; SMN2TSHRCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9568271 | 0.81 | SMN1; SMN2 (0.86) | SMN1; SMN2TSHRNPSR1USP2ALDH1A1 | |
| Bromide SCHEMBL8864504 | 0.80 | SMN1; SMN2 (0.84) | SMN1; SMN2TSHRNPSR1USP2ALDH1A1 | |
| SCHEMBL28890678 | 0.76 | KDM4E (0.56) | SMN1; SMN2TSHRKDM4EMEN1KMT2A | |
| SCHEMBL27926418 | 0.75 | CYP1A2 (0.68) | SMN1; SMN2TSHRCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1520208 | 0.75 | KDM4E (0.57) | SMN1; SMN2TSHRCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL10464937 | 0.75 | HTT (0.56) | SMN1; SMN2CYP1A2CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| US-6946565-B2 | Process for the preparation of an indole derivative | SMITHKLINE BEECHAM PLC (GB) | 2005-09-20 | — | — | US | disclosed |
| US-6583294-B2 | Reacting 3-chloro-3-carboxylate indole with 3-chloropropanol in presence of such as trichloroacetic acid to produce methyl 2-(3-chloropropoxy)-indole-3-carboxylate in high yield | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-06-24 | — | — | US | disclosed |
| US-20030114684-A1 | Preparation of methyl 2-(3-chloropropoxy)indole-3-carboxylate by reacting 3-chloro-3-carboxylate indole compound with 3-chloropropanol in presence of acid having pKa of 0-2 | SMITHKLINE BEECHAM PLC | 2003-06-19 | — | — | US | disclosed |
| US-20030083506-A1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATIVE | SMITHKLINE BEECHAM P.L.C. | 2003-05-01 | — | — | US | disclosed |
| US-20020091271-A1 | Process for the preparation of an indole derivative | SMITHKLINE BEECHAM PLC | 2002-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030083506-A1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATIVE | PRKD3, COMT, IDO1 | SMN1; SMN2 4842/4885TSHR 1840/4885CYP1A2 295/4885 |
| US-20030114684-A1 | Preparation of methyl 2-(3-chloropropoxy)indole-3-carboxylate by reacting 3-chloro-3-carboxylate indole compound with 3-chloropropanol in presence of acid having pKa of 0-2 | HTR3C, HTR3A, PRKD3 | SMN1; SMN2 4839/4885TSHR 1975/4885CYP1A2 488/4885 |
| US-20020091271-A1 | Process for the preparation of an indole derivative | PRKD3, COMT, IDO1 | SMN1; SMN2 4842/4885TSHR 1840/4885CYP1A2 295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.