Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 4/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868200 | 0.91 | ITGB3 (0.49) | SUV39H2CHRM4ITGB3ITGA2B | |
| SCHEMBL9235823 | 0.88 | SUV39H2 (0.44) | SUV39H2CHRM4PARP1PARP2HPGD | |
| SCHEMBL8866854 | 0.86 | MKNK1 (0.40) | SUV39H2CHRM4 | |
| SCHEMBL8867330 | 0.85 | SUV39H2 (0.44) | SUV39H2CHRM4THRBMGLL | |
| SCHEMBL8866386 | 0.83 | SUV39H2 (0.39) | SUV39H2CHRM4ITGB3ITGA2BHPGD | |
| SCHEMBL9235439 | 0.82 | SUV39H2 (0.43) | SUV39H2CHRM4PARP1PARP2HPGD | |
| SCHEMBL8866426 | 0.81 | SUV39H2 (0.42) | SUV39H2CHRM4ITGB3ITGA2B | |
| SCHEMBL8866874 | 0.80 | SUV39H2 (0.44) | SUV39H2CHRM4THRB | |
| SCHEMBL9235366 | 0.79 | SUV39H2 (0.44) | SUV39H2CHRM4ITGB3ITGA2BPARP1 | |
| SCHEMBL8865883 | 0.76 | PRSS1 (0.53) | SUV39H2ITGB3ITGA2BMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614531-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-03-25 | — | — | US | disclosed |
| EP-0668278-A1 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1995-08-23 | — | — | EP | disclosed |