Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1089194 | 0.80 | DGAT1 (0.36) | DGAT1CA1CA2CA7CA12 | |
| SCHEMBL11374066 | 0.79 | CA1 (0.32) | DGAT1CA1CA2CA7 | |
| SCHEMBL1088727 | 0.77 | CA1 (0.35) | DGAT1CA1CA2CA7CA12 | |
| SCHEMBL7576779 | 0.77 | LMNA (0.35) | DGAT1LMNAKMT2A | |
| SCHEMBL11387554 | 0.76 | DGAT1 (0.33) | DGAT1CA1CA2CA7CA12 | |
| SCHEMBL29488702 | 0.76 | DGAT1 (0.33) | DGAT1CA1CA2CA7CA12 | |
| SCHEMBL17094539 | 0.75 | LMNA (0.39) | DGAT1CA1CA2CA7CA12 | |
| SCHEMBL17094267 | 0.75 | LMNA (0.39) | DGAT1CA1CA2CA7CA12 | |
| SCHEMBL3183015 | 0.75 | LMNA (0.39) | DGAT1CA1CA2CA7CA12 | |
| SCHEMBL10608008 | 0.73 | SLC7A5 (0.41) | DGAT1CA1CA2CA7CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665746-A | BACTERICIDE | HOFFMANN-LA ROCHE INC. (US) | 1997-09-09 | — | — | US | disclosed |
| US-5594135-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 1997-01-14 | — | — | US | disclosed |
| US-5589473-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 1996-12-31 | — | — | US | disclosed |
| EP-0675122-A2 | Mono or bicyclic DNA gyrase inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-04 | — | — | EP | disclosed |