Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868076 | 1.00 | NPC1 (0.58) | NPC1RAB9ACYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL8868089 | 0.90 | NPC1 (0.58) | NPC1RAB9ACYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL8867463 | 0.83 | KMT2A (0.50) | NPC1RAB9ASMN1; SMN2MAPTHPGD | |
| SCHEMBL8867455 | 0.83 | KMT2A (0.50) | NPC1RAB9ASMN1; SMN2MAPTHPGD | |
| SCHEMBL1407210 | 0.78 | NPC1 (0.68) | NPC1RAB9ACYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL15033571 | 0.76 | NPC1 (0.70) | NPC1RAB9ACYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL12693 | 0.75 | ALDH1A1 (0.76) | NPC1RAB9ACYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL20237020 | 0.75 | SMN1; SMN2 (0.68) | NPC1RAB9ACYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL12694399 | 0.75 | NPC1 (0.68) | NPC1RAB9ACYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL1097789 | 0.75 | NPC1 (0.68) | NPC1RAB9ACYP2C9CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686484-A | ANTHELMINTICS, ACARICIDES, INSECTICIDES | SANKYO CO., LTD. (JP) | 1997-11-11 | — | — | US | disclosed |