Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | RXFP3 | Q9NSD7 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2062721 | 0.95 | RAB9A (0.44) | NPC1RAB9AMAPTKCNA5SMN1; SMN2 | |
| SCHEMBL2062908 | 0.89 | KCNA5 (0.38) | MAPTKCNA5ALDH1A1LMNAKCNH2 | |
| SCHEMBL2062950 | 0.88 | KCNA5 (0.47) | NPC1RAB9AMAPTKCNA5SMN1; SMN2 | |
| SCHEMBL886749 | 0.86 | KCNA5 (0.54) | NPC1RAB9AMAPTKCNA5SMN1; SMN2 | |
| SCHEMBL2063221 | 0.86 | ALDH1A1 (0.41) | NPC1RAB9AMAPTKCNA5SMN1; SMN2 | |
| SCHEMBL885665 | 0.86 | KCNA5 (0.42) | NPC1RAB9AMAPTKCNA5SMN1; SMN2 | |
| SCHEMBL884813 | 0.85 | KCNA5 (0.43) | NPC1RAB9AMAPTKCNA5SMN1; SMN2 | |
| SCHEMBL885892 | 0.85 | NPC1 (0.46) | NPC1RAB9AMAPTKCNA5SMN1; SMN2 | |
| SCHEMBL2063303 | 0.85 | KCNA5 (0.45) | NPC1RAB9AMAPTKCNA5SMN1; SMN2 | |
| SCHEMBL885452 | 0.84 | RPS6KB1 (0.38) | NPC1RAB9AMAPTKCNA5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |