Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349247 | 0.79 | NQO1 (0.47) | NQO1KDM4EALDH1A1MAPTPOLB | |
| SCHEMBL7354182 | 0.76 | NQO1 (0.42) | NQO1KDM4EALDH1A1MAPTPOLB | |
| SCHEMBL7354536 | 0.71 | CYP2C9 (0.69) | NQO1KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL8494601 | 0.71 | NQO1 (0.61) | NQO1KDM4EALDH1A1MAPTPOLB | |
| SCHEMBL7350870 | 0.71 | VKORC1 (0.67) | NQO1KDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL6276172 | 0.71 | NQO1 (0.73) | NQO1KDM4EALDH1A1MAPTPOLB | |
| SCHEMBL7400115 | 0.71 | ACHE (0.40) | NQO1 | |
| SCHEMBL17133407 | 0.70 | CYP2C9 (0.72) | NQO1KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL8087605 | 0.69 | NQO1 (0.69) | NQO1KDM4EALDH1A1MAPTPOLB | |
| SCHEMBL38652222 | 0.69 | NQO1 (0.69) | NQO1KDM4EALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686486-A | 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl b!pyran-2-ones useful to treat retroviral infections | PHARMACIA & UPJOHN COMPANY (US) | 1997-11-11 | — | — | US | claimed |
| US-5686486-A | 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl b!pyran-2-ones useful to treat retroviral infections | PHARMACIA & UPJOHN COMPANY (US) | 1997-11-11 | — | — | US | disclosed |