Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870309 | 0.90 | CA12 (0.42) | HPGDLMNAKDM4EALDH1A1GAA | |
| SCHEMBL8869499 | 0.85 | AR (0.42) | HPGDLMNAKDM4EALDH1A1GAA | |
| SCHEMBL8867836 | 0.82 | POLB (0.47) | HPGDLMNAKDM4EALDH1A1GAA | |
| SCHEMBL8869216 | 0.82 | P4HTM (0.46) | KDM4EMAOB | |
| SCHEMBL9574772 | 0.81 | ALDH1A1 (0.41) | HPGDLMNAKDM4EALDH1A1GAA | |
| SCHEMBL8868644 | 0.74 | HTT (0.53) | LMNAKDM4EALDH1A1MAPTCA1 | |
| SCHEMBL9574755 | 0.73 | KCNK3 (0.42) | HPGDLMNAKDM4EALDH1A1GAA | |
| SCHEMBL8867934 | 0.72 | GABRA5 (0.46) | HPGDALDH1A1MAPT | |
| SCHEMBL21379406 | 0.72 | NAMPT (0.48) | NAMPTMAOB | |
| SCHEMBL7856967 | 0.72 | MAOB (0.48) | HPGDLMNAKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |