Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869623 | 0.94 | P4HTM (0.49) | P4HTMLMNANPC1RAB9AKDM4E | |
| SCHEMBL8867860 | 0.94 | P4HTM (0.48) | P4HTMLMNANPC1RAB9AKDM4E | |
| SCHEMBL8867912 | 0.91 | P4HTM (0.49) | P4HTMLMNANPC1RAB9AKDM4E | |
| SCHEMBL8867737 | 0.91 | P4HTM (0.40) | P4HTMSMN1; SMN2PRKAA2 | |
| SCHEMBL8869402 | 0.90 | P4HTM (0.64) | P4HTMLMNANPC1RAB9AKDM4E | |
| SCHEMBL8870184 | 0.90 | KMT2A (0.46) | P4HTMNPC1RAB9AALDH1A1MMP8 | |
| SCHEMBL9142965 | 0.88 | P4HTM (0.57) | P4HTMLMNANPC1RAB9AKDM4E | |
| SCHEMBL8868040 | 0.88 | P4HTM (0.47) | P4HTMNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL8868011 | 0.86 | P4HTM (0.53) | P4HTMLMNANPC1RAB9AALDH1A1 | |
| SCHEMBL8869549 | 0.86 | P4HTM (0.50) | P4HTMLMNANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |