Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868512 | 0.90 | MAPT (0.47) | MAPTCYP3A4CYP2C9TSHRSMN1; SMN2 | |
| SCHEMBL8869748 | 0.89 | LMNA (0.49) | EPHX2MAPTCYP3A4CYP2C9TSHR | |
| SCHEMBL8868365 | 0.89 | CYP3A4 (0.46) | EPHX2MAPTCYP3A4CYP2C9TSHR | |
| SCHEMBL8868281 | 0.88 | LMNA (0.49) | EPHX2MAPTCYP3A4CYP2C9TSHR | |
| SCHEMBL8869285 | 0.88 | P4HTM (0.47) | MAPTSMN1; SMN2LMNAP4HTMBCL2L1 | |
| SCHEMBL8868297 | 0.88 | P4HTM (0.47) | MAPTSMN1; SMN2LMNAP4HTMBCL2L1 | |
| SCHEMBL8868372 | 0.87 | CYP3A4 (0.47) | EPHX2MAPTCYP3A4CYP2C9TSHR | |
| SCHEMBL8867950 | 0.86 | P4HTM (0.48) | MAPTSMN1; SMN2LMNAP4HTMBCL2L1 | |
| SCHEMBL8869506 | 0.86 | P4HTM (0.50) | MAPTSMN1; SMN2P4HTMBCL2L1MCL1 | |
| SCHEMBL8868703 | 0.86 | POLB (0.49) | LMNAP4HTMBCL2L1MCL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |