Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869748 | 0.92 | LMNA (0.49) | CYP3A4CYP2C9CYP2C19LMNAMAPT | |
| SCHEMBL8869180 | 0.89 | TSHR (0.50) | CYP3A4CYP2C9CYP2C19LMNAMAPT | |
| SCHEMBL8868365 | 0.89 | CYP3A4 (0.46) | CYP3A4CYP2C9CYP2C19LMNAMAPT | |
| SCHEMBL8868281 | 0.88 | LMNA (0.49) | CYP3A4CYP2C9CYP2C19LMNAMAPT | |
| SCHEMBL9018101 | 0.87 | EPHX2 (0.43) | CYP3A4CYP2C9CYP2C19LMNAMAPT | |
| SCHEMBL8869510 | 0.87 | LMNA (0.52) | CYP3A4CYP2C9CYP2C19LMNAMAPT | |
| SCHEMBL8869609 | 0.87 | EPHX2 (0.48) | CYP3A4CYP2C9CYP2C19LMNAMAPT | |
| SCHEMBL8868870 | 0.86 | LMNA (0.49) | CYP3A4CYP2C9CYP2C19LMNAMAPT | |
| SCHEMBL8868205 | 0.86 | ALDH1A1 (0.45) | CYP3A4CYP2C9CYP2C19LMNAMAPT | |
| SCHEMBL9140099 | 0.86 | LMNA (0.50) | CYP3A4CYP2C9CYP2C19LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |