Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.64 |
| ▸ | DRD2 | P14416 | 5/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.64 |
| ▸ | HTR1A | P08908 | 4/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.64 |
| ▸ | HTR2A | P28223 | 4/20 | 0.64 |
| ▸ | HTR2C | P28335 | 4/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.64 |
| ▸ | HRH1 | P35367 | 4/20 | 0.64 |
| ▸ | DRD3 | P35462 | 4/20 | 0.64 |
| ▸ | HTR2B | P41595 | 4/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6843471 | 0.92 | LMNA (0.76) | LMNAMAPTSMN1; SMN2CYP2D6DRD2 | |
| SCHEMBL21525461 | 0.92 | MAPT (0.76) | LMNAMAPTSMN1; SMN2CYP2D6DRD2 | |
| SCHEMBL502507 | 0.88 | MEN1 (0.81) | LMNAMAPTSMN1; SMN2CYP2D6DRD2 | |
| SCHEMBL27083995 | 0.86 | CYP2D6 (0.65) | LMNAMAPTSMN1; SMN2CYP2D6DRD2 | |
| SCHEMBL8520671 | 0.84 | ITGB2 (0.62) | LMNAMAPTSMN1; SMN2CYP2D6DRD2 | |
| SCHEMBL14697664 | 0.84 | LMNA (0.60) | LMNAMAPTSMN1; SMN2CYP2D6DRD2 | |
| SCHEMBL5880486 | 0.84 | HDAC3 (0.59) | LMNAMAPTSMN1; SMN2CYP2D6DRD2 | |
| Perphenazine SCHEMBL246992 | 0.83 | MAPT (0.78) | LMNAMAPTSMN1; SMN2CYP2D6DRD2 | |
| Perphenazine SCHEMBL1069999 | 0.83 | LMNA (0.78) | LMNAMAPTSMN1; SMN2CYP2D6DRD2 | |
| SCHEMBL29724166 | 0.82 | CYP2D6 (0.71) | LMNAMAPTSMN1; SMN2CYP2D6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654323-A | 2-NITROGEN-CONTAINING FUNCTIONAL GROUP-HALOBENZOTHIAZOLES; ANALGESICS; ANTIINFLAMMATORY AND HYPOTENSIVE AGENTS; INHIBITORS OF CYTOKINES (INCLUDING TUMOR NECROSIS FACTOR) AND PHOSPHOLIPASE; SEPTIC SHOCK | ADIR ET COMPAGNIE (FR) | 1997-08-05 | — | — | US | disclosed |
| US-5597819-A | ANTIINFLAMMATORY AGENTS | ADIR ET COMPAGNIE (FR) | 1997-01-28 | — | — | US | disclosed |
| US-5550143-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 1996-08-27 | — | — | US | disclosed |