Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.59 |
| ▸ | BCHE | P06276 | 3/20 | 0.59 |
| ▸ | ACHE | P22303 | 3/20 | 0.59 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.58 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.58 |
| ▸ | ITGAL | P20701 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14697658 | 0.87 | HDAC3 (0.58) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL12311066 | 0.86 | MEN1 (0.69) | BCHEACHELMNAMAPTMEN1 | |
| SCHEMBL6843471 | 0.86 | LMNA (0.76) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL8869747 | 0.84 | LMNA (0.64) | ITGB2ICAM1ITGALLMNAMAPT | |
| SCHEMBL27083989 | 0.81 | HDAC3 (0.67) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5880427 | 0.81 | ITGB2 (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL8520671 | 0.81 | ITGB2 (0.62) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL21449100 | 0.80 | HDAC3 (0.54) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL21449098 | 0.80 | HDAC6 (0.77) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6637375 | 0.79 | LMNA (0.74) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119089-B2 | Phenothiazine kinesin inhibitors | CYTOKINETICS, INC. (US) | 2006-10-10 | — | — | US | disclosed |
| US-6992082-B2 | Phenothiazine kinesin inhibitors | CYTOKINETICS, INC. (US) | 2006-01-31 | — | — | US | disclosed |
| US-20060014736-A1 | Phenothiazine kinesin inhibitors | CYTOKINETICS, INC. (US) | 2006-01-19 | — | — | US | disclosed |
| US-20040132719-A1 | Phenothiazine kinesin inhibitors | CYTOKINETICS, INC. | 2004-07-08 | — | — | US | disclosed |
| EP-1360180-A1 | PHENOTHIAZINE KINESIN INHIBITORS | Cytokinetics, Inc. (US) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002057244-A1 | PHENOTHIAZINE KINESIN INHIBITORS | CYTOKINETICS, INC. (US) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132719-A1 | Phenothiazine kinesin inhibitors | KIF5B, KIF2C, KIF15 | HDAC3 1180/4885HDAC4 425/4885HDAC1 244/4885 |
| US-20060014736-A1 | Phenothiazine kinesin inhibitors | KIF5B, KIF2C, KIF15 | HDAC3 1142/4885HDAC4 392/4885HDAC1 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.