Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868602 | 0.95 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2P4HTMPOLB | |
| SCHEMBL8869213 | 0.92 | RAB9A (0.53) | NPC1RAB9ASMN1; SMN2P4HTMPOLB | |
| SCHEMBL8869675 | 0.91 | BCL2L1 (0.50) | NPC1RAB9ASMN1; SMN2P4HTMPOLB | |
| SCHEMBL8868530 | 0.90 | P4HTM (0.49) | NPC1RAB9ASMN1; SMN2P4HTMPOLB | |
| SCHEMBL8867993 | 0.89 | P4HTM (0.46) | NPC1RAB9ASMN1; SMN2P4HTMPOLB | |
| SCHEMBL9141114 | 0.89 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2P4HTMPOLB | |
| SCHEMBL8870849 | 0.89 | RAB9A (0.54) | NPC1RAB9ASMN1; SMN2P4HTMPOLB | |
| SCHEMBL8869726 | 0.89 | P4HTM (0.54) | NPC1RAB9ASMN1; SMN2P4HTMPOLB | |
| SCHEMBL8868613 | 0.89 | RAB9A (0.50) | NPC1RAB9ASMN1; SMN2P4HTMPOLB | |
| SCHEMBL8868669 | 0.89 | P4HTM (0.49) | NPC1RAB9ASMN1; SMN2P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |