Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870022 | 0.87 | CYP1A2 (0.62) | MAPTTDP1TP53CYP3A4MAPK1 | |
| SCHEMBL9570476 | 0.87 | MAPT (0.47) | MAPTTDP1TP53CYP3A4MAPK1 | |
| Bromide SCHEMBL8869416 | 0.86 | MAPT (0.46) | MAPTTDP1TP53CYP3A4MAPK1 | |
| SCHEMBL8053156 | 0.75 | CYP2D6 (0.71) | MAPTTDP1TP53CYP3A4MAPK1 | |
| SCHEMBL29724166 | 0.75 | CYP2D6 (0.71) | MAPTTDP1TP53CYP3A4MAPK1 | |
| SCHEMBL10614342 | 0.75 | BCHE (0.47) | MAPTTP53BCHECYP1A2HTR1A | |
| SCHEMBL21436140 | 0.74 | CYP2D6 (0.70) | MAPTTDP1TP53CYP3A4MAPK1 | |
| SCHEMBL30349813 | 0.74 | CYP2D6 (0.70) | MAPTTDP1TP53CYP3A4MAPK1 | |
| SCHEMBL8428842 | 0.73 | MEN1 (0.78) | MAPTMAPK1KDM4EMEN1KMT2A | |
| SCHEMBL9104807 | 0.72 | MAPT (0.73) | MAPTTDP1TP53CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654323-A | 2-NITROGEN-CONTAINING FUNCTIONAL GROUP-HALOBENZOTHIAZOLES; ANALGESICS; ANTIINFLAMMATORY AND HYPOTENSIVE AGENTS; INHIBITORS OF CYTOKINES (INCLUDING TUMOR NECROSIS FACTOR) AND PHOSPHOLIPASE; SEPTIC SHOCK | ADIR ET COMPAGNIE (FR) | 1997-08-05 | — | — | US | disclosed |
| US-5550143-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 1996-08-27 | — | — | US | disclosed |