Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.73 |
| ▸ | TP53 | P04637 | 4/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.73 |
| ▸ | RAD52 | P43351 | 3/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | USP2 | O75604 | 2/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.62 |
| ▸ | DRD2 | P14416 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.62 |
| ▸ | HTR1A | P08908 | 4/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22024566 | 0.96 | MAPT (0.72) | MAPTTDP1TP53CYP3A4MAPK1 | |
| SCHEMBL9102304 | 0.93 | MAPT (0.64) | MAPTTDP1TP53CYP3A4MAPK1 | |
| SCHEMBL48681 | 0.88 | MEN1 (0.58) | MAPTTDP1TP53CYP3A4MAPK1 | |
| SCHEMBL30115198 | 0.88 | MEN1 (0.58) | MAPTTDP1TP53CYP3A4MAPK1 | |
| SCHEMBL30115197 | 0.88 | MEN1 (0.58) | MAPTTDP1TP53CYP3A4MAPK1 | |
| SCHEMBL8444747 | 0.87 | MEN1 (0.57) | MAPTTDP1TP53CYP3A4MAPK1 | |
| SCHEMBL48847 | 0.87 | MEN1 (0.57) | MAPTTDP1TP53CYP3A4MAPK1 | |
| SCHEMBL9104151 | 0.85 | MAPT (0.58) | MAPTTDP1TP53CYP3A4MAPK1 | |
| SCHEMBL9100929 | 0.85 | MAPT (0.55) | MAPTTDP1TP53CYP3A4MAPK1 | |
| Prochlorperazine SCHEMBL40855 | 0.85 | MAPT (1.00) | MAPTTDP1TP53CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230002335-A1 | SMALL MOLECULE ENHANCEMENT OF 20S PROTEASOME ACTIVITY TARGETS INTRINSICALLY DISORDERED PROTEINS | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2023-01-05 | — | — | US | disclosed |
| US-11358942-B2 | Substituted phenothiazines as proteasome activators | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200165216-A1 | SMALL MOLECULE PROTEASOME ACTIVATORS AND USES THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2020-05-28 | — | — | US | disclosed |
| WO-2018226589-A9 | SMALL MOLECULE PROTEOSOME ACTIVATORS AND USES THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2019-10-10 | — | — | WO | disclosed |
| US-8192948-B1 | Chemifluorescent substrate for peroxide and peroxidase detection | PIERCE BIOTECHNOLOGY, INC. (US) | 2012-06-05 | — | — | US | disclosed |
| EP-0361470-B1 | Method for the chemiluminescence assay of the activity of peroxidase | FUJIREBIO KK (JP) | 1993-12-22 | — | — | EP | disclosed |
| US-5171668-A | Measuring light emitted from contacting (iso)luminol, peroxide, peroxidase activity enhancer, such as indoanilines, phenolindophenol and N-methylphenothiazine, with labeled peroxidase antibody-antigen complex | FUJIREBIO INC. (JP) | 1992-12-15 | — | — | US | disclosed |
| EP-0361470-A2 | Method for the chemiluminescence assay of the activity of peroxidase | FUJIREBIO INC. (JP) | 1990-04-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11358942-B2 | Substituted phenothiazines as proteasome activators | PSMG3, ADRM1, PSME3 | MAPT 60/4885TDP1 386/4885TP53 56/4885 |
| US-20230002335-A1 | SMALL MOLECULE ENHANCEMENT OF 20S PROTEASOME ACTIVITY TARGETS INTRINSICALLY DISORDERED PROTEINS | PSMG3, PSME3, PSME1 | MAPT 165/4885TDP1 601/4885TP53 161/4885 |
| US-20200165216-A1 | SMALL MOLECULE PROTEASOME ACTIVATORS AND USES THEREOF | PSMG3, PSME3, PSMB2 | MAPT 193/4885TDP1 712/4885TP53 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.