Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | TERT | O14746 | 3/20 | 0.51 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 5/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.45 |
| ▸ | PRKDC | P78527 | 2/20 | 0.45 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27389897 | 0.98 | IP6K1 (0.53) | MAP4K4TERTIP6K1EGFRPDE3B | |
| SCHEMBL28695062 | 0.86 | EGFR (0.47) | MAP4K4TERTIP6K1EGFRPIK3CD | |
| SCHEMBL8871292 | 0.84 | PRKDC (0.50) | EGFRPDE3BPDE3APRKDCPIK3CD | |
| SCHEMBL31391376 | 0.76 | TERT (0.50) | MAP4K4TERTIP6K1PDE3BPDE3A | |
| SCHEMBL27971129 | 0.76 | TERT (0.46) | MAP4K4TERTIP6K1PDE3BPDE3A | |
| SCHEMBL28306659 | 0.75 | TERT (0.57) | MAP4K4TERTIP6K1PDE3BPDE3A | |
| SCHEMBL30979879 | 0.74 | EGFR (0.56) | EGFRPIK3CDPIK3CAMAPTABL1 | |
| SCHEMBL27389898 | 0.73 | EGFR (0.51) | EGFRPIK3CDPIK3CA | |
| SCHEMBL28874935 | 0.73 | TERT (0.56) | MAP4K4TERTIP6K1MAPT | |
| SCHEMBL8871494 | 0.73 | MAP4K4 (0.68) | MAP4K4TERTIP6K1PRKDCIP6K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616582-A | Use as anticancer agents; e.g. gefitinib | ZENECA LIMITED (GB) | 1997-04-01 | — | — | US | disclosed |
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| EP-0566226-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1995-11-08 | — | — | EP | disclosed |
| US-5457105-A | anticancer use; e.g. 4-(3'-chloro-4'-fluoroanilino)-6,7-dimethoxyquinazoline (gefitinib) | ZENECA LIMITED (GB) | 1995-10-10 | — | — | US | disclosed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | disclosed |
| EP-0566226-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1993-10-20 | — | — | EP | disclosed |