Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31369670 | 1.00 | KCNH2 (0.51) | KCNH2HTR2CCYP2C19MEN1KMT2A | |
| SCHEMBL8871025 | 1.00 | KCNH2 (0.51) | KCNH2HTR2CCYP2C19MEN1KMT2A | |
| SCHEMBL20835449 | 1.00 | KCNH2 (0.51) | KCNH2HTR2CCYP2C19MEN1KMT2A | |
| SCHEMBL7773300 | 0.83 | KCNH2 (0.52) | KCNH2CYP2C19SCN3ADPP4 | |
| SCHEMBL7769177 | 0.83 | KCNH2 (0.52) | KCNH2CYP2C19SCN3ADPP4 | |
| SCHEMBL7769176 | 0.83 | KCNH2 (0.52) | KCNH2CYP2C19SCN3ADPP4 | |
| SCHEMBL7775249 | 0.83 | KCNH2 (0.52) | KCNH2CYP2C19SCN3ADPP4 | |
| SCHEMBL2038087 | 0.83 | KCNH2 (0.56) | KCNH2CYP2C19SCN3ADPP4S1PR4 | |
| SCHEMBL135106 | 0.82 | KCNH2 (0.56) | KCNH2CYP2C19SCN3ADPP4S1PR4 | |
| SCHEMBL5696388 | 0.82 | KCNH2 (0.56) | KCNH2CYP2C19SCN3ADPP4S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610144-A | CHOLECYSTOKININ OR GASTRIN ANTAGONISTS; NERVOUS SYSTEM AND GASTROINTESTINAL DISORDERS | RHONE-POULENC RORER S.A. (FR) | 1997-03-11 | — | — | US | disclosed |