Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalic Acid SCHEMBL5875193 | 0.90 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDTDP1TSHR | |
| Salicylic Acid SCHEMBL22188484 | 0.86 | KDM4E (0.54) | KDM4EALDH1A1HPGDTDP1TSHR | |
| Phthalic Acid SCHEMBL8434834 | 0.85 | ALDH1A1 (0.55) | KDM4EALDH1A1HPGDTDP1TSHR | |
| Anthranilic Acid SCHEMBL19019692 | 0.83 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDTDP1TSHR | |
| Anthranilic Acid SCHEMBL29420044 | 0.83 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDTDP1TSHR | |
| Salicylic Acid SCHEMBL106469 | 0.82 | KDM4E (0.79) | KDM4EALDH1A1HPGDTDP1TSHR | |
| Bicarbonate SCHEMBL988121 | 0.82 | ALDH1A1 (0.71) | KDM4EALDH1A1TDP1TSHRSMN1; SMN2 | |
| Bicarbonate SCHEMBL988119 | 0.82 | ALDH1A1 (0.71) | KDM4EALDH1A1TDP1TSHRCA9 | |
| Salicylic Acid SCHEMBL1002331 | 0.82 | KDM4E (0.61) | KDM4EALDH1A1HPGDTDP1TSHR | |
| Oxalic Acid SCHEMBL153608 | 0.81 | ALDH1A1 (0.68) | KDM4EALDH1A1TDP1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3280030-B2 | — | — | 2002-04-30 | — | — | JP | claimed |
| EP-0749450-B1 | COATING COMPOSITION AND PROCESS FOR FORMING CURED FILM | NIPPON PAINT CO LTD (JP) | 2000-07-05 | — | — | EP | claimed |
| US-5766767-A | Coating composition process for forming cured film and coated article | NIPPON PAINT CO., LTD. (JP) | 1998-06-16 | — | — | US | claimed |
| EP-0749450-A1 | COATING COMPOSITION, PROCESS FOR FORMING CURED FILM AND COATED ARTICLE | NIPPON PAINT CO., LTD. (JP) | 1996-12-27 | — | — | EP | claimed |
| WO-1995023820-A1 | COATING COMPOSITION, PROCESS FOR FORMING CURED FILM AND COATED ARTICLE | NIPPON PAINT CO., LTD. (JP) | 1995-09-08 | — | — | WO | claimed |
| EP-3572484-B1 | ASHLESS OR REDUCED ASH QUATERNARY DETERGENTS | LUBRIZOL CORP (US) | 2021-05-05 | — | — | EP | disclosed |
| EP-3572484-A1 | ASHLESS OR REDUCED ASH QUATERNARY DETERGENTS | The Lubrizol Corporation (US) | 2019-11-27 | — | — | EP | disclosed |
| US-10407641-B2 | Ashless or reduced ash quaternary detergents | THE LUBRIZOL CORPORATION (US) | 2019-09-10 | — | — | US | disclosed |
| EP-2403930-B1 | ASHLESS OR REDUCED ASH QUATERNARY DETERGENTS | LUBRIZOL CORP (US) | 2019-08-07 | — | — | EP | disclosed |
| US-20180134982-A1 | ASHLESS OR REDUCED ASH QUATERNARY DETERGENTS | LUBRIZOL CORP (US) | 2018-05-17 | — | — | US | disclosed |
| US-9890347-B2 | Ashless or reduced ash quaternary detergents | THE LUBRIZOL CORPORATION (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170022444-A1 | ASHLESS OR REDUCED ASH QUATERNARY DETERGENTS | LUBRIZOL CORP (US) | 2017-01-26 | — | — | US | disclosed |
| WO-2010101801-A1 | ASHLESS OR REDUCED ASH QUATERNARY DETERGENTS | THE LUBRIZOL CORPORATION (US) | 2010-09-10 | — | — | WO | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| EP-0749450-B1 | COATING COMPOSITION AND PROCESS FOR FORMING CURED FILM | NIPPON PAINT CO LTD (JP) | 2000-07-05 | — | — | EP | disclosed |
| EP-0953587-A2 | Coating composition containing a non-halogen onium salt | NIPPON PAINT CO., LTD. (JP) | 1999-11-03 | — | — | EP | disclosed |
| US-5766767-A | Coating composition process for forming cured film and coated article | NIPPON PAINT CO., LTD. (JP) | 1998-06-16 | — | — | US | disclosed |
| EP-0749450-A1 | COATING COMPOSITION, PROCESS FOR FORMING CURED FILM AND COATED ARTICLE | NIPPON PAINT CO., LTD. (JP) | 1996-12-27 | — | — | EP | disclosed |
| WO-1995023820-A1 | COATING COMPOSITION, PROCESS FOR FORMING CURED FILM AND COATED ARTICLE | NIPPON PAINT CO., LTD. (JP) | 1995-09-08 | — | — | WO | disclosed |