Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 9/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8053306 | 0.85 | OPRL1 (0.61) | OPRL1OPRM1OPRK1CHRM1EGLN1 | |
| SCHEMBL13310538 | 0.83 | OPRL1 (0.46) | OPRL1OPRM1OPRK1CHRM1EGLN1 | |
| SCHEMBL2302362 | 0.80 | CHRM1 (0.52) | OPRL1OPRM1OPRK1CHRM1EGLN1 | |
| SCHEMBL26025921 | 0.77 | OPRL1 (0.52) | OPRL1OPRM1OPRK1CHRM1EGLN1 | |
| SCHEMBL2490968 | 0.74 | OPRM1 (0.59) | OPRL1OPRM1OPRK1EGLN1 | |
| SCHEMBL30548955 | 0.74 | OPRM1 (0.59) | OPRL1OPRM1OPRK1EGLN1 | |
| SCHEMBL8320599 | 0.74 | OPRL1 (0.67) | OPRL1OPRM1OPRK1EGLN1 | |
| SCHEMBL13479964 | 0.74 | OPRL1 (0.69) | OPRL1OPRM1OPRK1CHRM1EGLN1 | |
| SCHEMBL13001593 | 0.73 | OPRL1 (0.59) | OPRL1OPRM1OPRK1EGLN1 | |
| SCHEMBL8860126 | 0.72 | PGR (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5621116-A | CHEMICAL INTERMEDIATES; MEMORY ENHANCERS FOR TREATMENT OF ALZHEIMER*S, ANALGESICS, ANTICONVULSANTS | HOECHST MARION ROUSSEL, INC. (US) | 1997-04-15 | — | — | US | disclosed |
| US-5464846-A | Learning enhancement, Alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0415102-B1 | 1,3-Dihydro-1-(pyridinylamino)-2H-indol-2-ones, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-02-01 | — | — | EP | disclosed |
| US-5179119-A | Cognition activators; alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-01-12 | — | — | US | disclosed |
| US-5053511-A | Analgesics; anticonvulsants; treatment for alzheimers disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0415102-A1 | 1,3-Dihydro-1-(pyridinylamino)-2H-indol-2-ones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-03-06 | — | — | EP | disclosed |