SCHEMBL8872802

SCHEMBL8872802

CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C(=O)OC)cc1

nearest known ligand 0.81

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 3/20 0.64
AGTR2 P50052 3/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8873549 0.93 AGTR1 (0.62) AGTR1AGTR2
SCHEMBL8873855 0.91 AGTR1 (0.63) AGTR1AGTR2
SCHEMBL8558632 0.91 AGTR1 (0.62) AGTR1AGTR2
SCHEMBL683347 0.89 AGTR1 (0.67) AGTR1AGTR2
SCHEMBL21125169 0.89 AGTR1 (0.55) AGTR1AGTR2
SCHEMBL9301037 0.89 AGTR1 (0.66) AGTR1AGTR2
SCHEMBL21083559 0.88 AGTR1 (0.57) AGTR1AGTR2
SCHEMBL8559031 0.88 AGTR1 (0.65) AGTR1AGTR2
SCHEMBL8565668 0.88 AGTR1 (0.62) AGTR1AGTR2
SCHEMBL21125327 0.87 AGTR1 (0.54) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5700938-A Intermediates for imidazopyridine derivatives EISAI CO., LTD. (JP) 1997-12-23 US disclosed
US-5618969-A Intermediates for imidazopyridines EISAI CO., LTD. (JP) 1997-04-08 US disclosed
US-5608068-A Process for the preparation of imidazopyridine derivatives and intermediates EISAI CO., LTD. (JP) 1997-03-04 US disclosed
US-5587504-A Sulfonyloxy-biphenylcarboxylic ester derivatives which are intermediates EISAI CO., LTD. (JP) 1996-12-24 US disclosed
US-5557002-A Process for the preparation of biphenyl containing intermediates useful in making angiotensin II receptor antagonists EISAI CO., LTD. (JP) 1996-09-17 US disclosed
US-5554757-A Process for the preparation of imidazopyridine derivatives, and intermediates therefore EISAI CO., LTD. (JP) 1996-09-10 US disclosed
EP-0627433-A1 PROCESS FOR PRODUCING IMIDAZOPYRIDINE DERIVATIVE AND INTERMEDIATE Eisai Co., Ltd. (JP) 1994-12-07 EP disclosed
US-5338737-A Biphenyl oxadiazoles and thiadiazoles as angiotensin II antagonists WARNER-LAMBERT COMPANY (US) 1994-08-16 US disclosed
US-5210204-A Hypotensive agents and cardiovascular disorders WARNER-LAMBERT COMPANY (US) 1993-05-11 US disclosed