Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8872167 | 0.89 | PTPN1 (0.58) | KMT2ATRPA1ABHD6PTPN1MAPT | |
| SCHEMBL8872446 | 0.87 | KMT2A (0.74) | KMT2AMEN1ATMPTPN1MAPT | |
| SCHEMBL8871718 | 0.86 | MAPT (0.53) | KMT2ATRPA1ABHD6MAPTPOLB | |
| SCHEMBL9322607 | 0.84 | KMT2A (0.76) | KMT2AMEN1ATMPTPN1MAPT | |
| SCHEMBL9322643 | 0.82 | KMT2A (0.78) | KMT2AMEN1ATMPTPN1MAPT | |
| SCHEMBL9323818 | 0.81 | KMT2A (0.76) | KMT2AMEN1ATMPTPN1MAPT | |
| SCHEMBL9322747 | 0.81 | KMT2A (0.71) | KMT2AMEN1ATMPTPN1POLB | |
| SCHEMBL8871853 | 0.80 | KMT2A (0.73) | KMT2AMEN1ATMPTPN1MAPT | |
| SCHEMBL9325709 | 0.78 | KMT2A (0.67) | KMT2AMEN1ATMMAPT | |
| SCHEMBL6978776 | 0.78 | KMT2A (0.70) | KMT2AMEN1ATMPTPN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681843-A | ANTIDIABETIC; ALDOSE REDUCTASE INHIBITOR WITHOUT SUBSTANTIALLY INHIBITING ALDEHYDE REDUCATASE | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-28 | — | — | US | disclosed |
| EP-0718289-A1 | Novel parabanic acid derivatives as aldose reductase inhibitors | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-06-26 | — | — | EP | disclosed |