Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.38 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.33 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.33 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.33 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8874359 | 1.00 | MITF (0.40) | MITFHSP90AA1RAB9AMEN1KMT2A | |
| SCHEMBL9238629 | 0.88 | CYP2A6 (0.40) | MAPTNOTUMTSHRCYP2A6MAOA | |
| Fumaric Acid SCHEMBL8874309 | 0.88 | CYP3A4 (0.41) | MITFHSP90AA1RAB9AMEN1KMT2A | |
| Fumaric Acid SCHEMBL8874318 | 0.88 | CYP3A4 (0.41) | MITFHSP90AA1RAB9AMEN1KMT2A | |
| SCHEMBL7284322 | 0.83 | HTR2A (0.44) | RAB9AMEN1KMT2AMAPTNOTUM | |
| Fumaric Acid SCHEMBL8875813 | 0.81 | MEN1 (0.38) | MEN1KMT2AMAPK1NOTUMTP53 | |
| Fumaric Acid SCHEMBL8875809 | 0.81 | MEN1 (0.38) | MEN1KMT2AMAPK1NOTUMTP53 | |
| Fumaric Acid SCHEMBL8873381 | 0.79 | BCHE (0.34) | MITFHSP90AA1RAB9AMEN1KMT2A | |
| Fumaric Acid SCHEMBL8873388 | 0.79 | BCHE (0.34) | MITFHSP90AA1RAB9AMEN1KMT2A | |
| Fumaric Acid SCHEMBL8873690 | 0.79 | HRH1 (0.44) | MITFHSP90AA1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |