Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 0.62 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | HTR1B | P28222 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.57 |
| ▸ | HTR1F | P30939 | 2/20 | 0.57 |
| ▸ | HTR1D | P28221 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8874424 | 1.00 | HTR6 (0.62) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL7104621 | 0.85 | HTR1B (0.65) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL7104625 | 0.85 | HTR1B (0.65) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8699573 | 0.83 | HTR6 (0.64) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8699581 | 0.83 | HTR6 (0.64) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8790536 | 0.82 | HTR1B (0.64) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8790532 | 0.82 | HTR1B (0.64) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8789718 | 0.82 | HTR6 (0.56) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| SCHEMBL8789712 | 0.82 | HTR6 (0.56) | HTR6HTR1AHTR1BHTR2CHTR1F | |
| Hydrochloric Acid SCHEMBL8886514 | 0.81 | HTR6 (0.55) | HTR6HTR1AHTR1BHTR2CHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618834-A | Indole derivatives in the treatment of emesis | PFIZER INC. (US) | 1997-04-08 | — | — | US | disclosed |
| US-5607951-A | SEROTONIN AGONIST FOR NERVOUS SYSTEM DISORDERS, ANALGESICS AND PSYCHOTHERAPEUTICS | PFIZER INC (US) | 1997-03-04 | — | — | US | disclosed |
| US-5578612-A | Indole derivatives | PFIZER INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5559129-A | SEROTONIN (5HT1) ANTAGONIST FOR TREATMENT OF DEPRESSION, ANXIETY, EATING DISORDERS, OBESITY, DRUG ABUSE, HEADACHES, AND PAIN | PFIZER INC (US) | 1996-09-24 | — | — | US | disclosed |
| US-5559246-A | PROCESS OF DEHYDROHALOGENATION FOR CYCLIZATION TO PRODUCE PSYCHOTHERAPEUTIC AGENTS AND ANTISEROTONIN ANTAGONIST | PFIZER INC. (US) | 1996-09-24 | — | — | US | disclosed |
| US-5545644-A | SEROTONIN AGONISTS; HYPOTENSIVE AND ANXIOLYTIC AGENTS; ANALGESICS; ANTIDEPRESSANTS; EATING DISORDERS; DRUG ABUSE; HEADACHES; VASCULAR DISORDERS | PFIZER INC. (US) | 1996-08-13 | — | — | US | disclosed |
| EP-0714659-A2 | Indole derivatives in the treatment of emesis | Pfizer Limited (GB) | 1996-06-05 | — | — | EP | disclosed |