Sugi Predict

Sugi Predict / Compounds / SCHEMBL887463

SCHEMBL887463

SCHEMBL887463

C=CCO[C@@H]1C[C@H](n2ccc(N)nc2=O)O[C@@H]1CO[Si](C)(C)C(C)(C)C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.43
▸ PDE3A Q14432 3/20 0.38
▸ LMNA P02545 3/20 0.38
▸ CACNA1F O60840 2/20 0.38
▸ ALB P02768 2/20 0.38
▸ MAPT P10636 2/20 0.38
▸ CACNA1D Q01668 2/20 0.38
▸ CACNA1S Q13698 2/20 0.38
▸ CACNA1C Q13936 2/20 0.38
▸ POLG P54098 2/20 0.37
▸ TOP2A P11388 5/20 0.37
▸ P2RY2 P41231 3/20 0.36
▸ P2RY4 P51582 3/20 0.36
▸ P2RY6 Q15077 2/20 0.36
▸ PDE4D Q08499 1/20 0.36
▸ SLC29A1 Q99808 1/20 0.36
▸ THRB P10828 1/20 0.35
▸ MTOR P42345 1/20 0.35
▸ MDM2 Q00987 1/20 0.35
▸ NCOA1 Q15788 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL429747 1.00 POLB (0.43) POLBPDE3ALMNACACNA1FALB
SCHEMBL429748 1.00 POLB (0.43) POLBPDE3ALMNACACNA1FALB
SCHEMBL734839 0.87 POLB (0.46) POLBPDE3ALMNACACNA1FALB
SCHEMBL21317432 0.87 POLB (0.46) POLBPDE3ALMNACACNA1FALB
SCHEMBL11986900 0.87 POLB (0.46) POLBPDE3ALMNACACNA1FALB
SCHEMBL4580611 0.87 POLB (0.46) POLBPDE3ALMNACACNA1FALB
SCHEMBL21778225 0.85 POLB (0.43) POLBPDE3ALMNACACNA1FALB
SCHEMBL16489130 0.85 POLB (0.43) POLBPDE3ALMNACACNA1FALB
SCHEMBL24090515 0.85 TOP2A (0.41) TOP2A
SCHEMBL4580042 0.85 POLB (0.44) POLBPDE3ALMNACACNA1FALB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10000801-B2 Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2018-06-19 — — US disclosed
US-10000801-B2 Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2018-06-19 — — US disclosed
US-20170114403-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2017-04-27 — — US disclosed
US-20170114403-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2017-04-27 — — US disclosed
US-9528151-B2 Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2016-12-27 — — US disclosed
US-20140315191-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2014-10-23 — — US disclosed
US-20130280700-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2013-10-24 — — US disclosed
US-7883869-B2 for sequencing single-stranded DNA by employing a nanopore and modified nucleotides THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2011-02-08 — — US disclosed
US-20100092952-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-04-15 — — US disclosed