Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.38 |
| ▸ | ALB | P02768 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.38 |
| ▸ | POLG | P54098 | 2/20 | 0.37 |
| ▸ | TOP2A | P11388 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.36 |
| ▸ | P2RY4 | P51582 | 3/20 | 0.36 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21778225 | 1.00 | POLB (0.43) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL4580611 | 0.87 | POLB (0.46) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL734839 | 0.87 | POLB (0.46) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL11986900 | 0.87 | POLB (0.46) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL21317432 | 0.87 | POLB (0.46) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL887463 | 0.85 | POLB (0.43) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL429748 | 0.85 | POLB (0.43) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL429747 | 0.85 | POLB (0.43) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL21778221 | 0.84 | LMNA (0.50) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL16489129 | 0.84 | LMNA (0.50) | POLBLMNAPDE3ACACNA1FALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9932623-B2 | Nucleotide analogs | ABBOTT MOLECULAR INC. (US) | 2018-04-03 | — | — | US | disclosed |
| US-9932623-B2 | Nucleotide analogs | ABBOTT MOLECULAR INC. (US) | 2018-04-03 | — | — | US | disclosed |
| US-20150050697-A1 | NUCLEOTIDE ANALOGS | ABBOTT MOLECULAR INC. | 2015-02-19 | — | — | US | disclosed |
| US-20150050697-A1 | NUCLEOTIDE ANALOGS | ABBOTT MOLECULAR INC. | 2015-02-19 | — | — | US | disclosed |
| US-20150051113-A1 | NUCLEOTIDE ANALOGS | ABBOTT MOLECULAR INC. | 2015-02-19 | — | — | US | disclosed |
| US-20150051113-A1 | NUCLEOTIDE ANALOGS | ABBOTT MOLECULAR INC. | 2015-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150050697-A1 | NUCLEOTIDE ANALOGS | NUDT1, NT5C3B, RNGTT | POLB 32/4885LMNA 575/4885PDE3A 889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.