Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 7/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8874912 | 0.86 | TP53 (0.42) | SCN9AEGLN1ALDH1A1GAAMAPT | |
| SCHEMBL8873829 | 0.83 | ALDH1A1 (0.55) | ALDH1A1GAAMAPTRECQLCYP1A2 | |
| SCHEMBL8874321 | 0.83 | ALDH1A1 (0.44) | ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8875521 | 0.82 | ALDH1A1 (0.42) | SCN9AEGLN1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL8874764 | 0.80 | KCNQ2 (0.50) | SCN9AALDH1A1GAAMAPTRECQL | |
| Water SCHEMBL9391496 | 0.79 | KCNQ2 (0.49) | SCN9AALDH1A1GAAMAPTRECQL | |
| Water SCHEMBL9391493 | 0.79 | KCNQ2 (0.49) | SCN9AALDH1A1GAAMAPTRECQL | |
| SCHEMBL8874241 | 0.75 | ALDH1A1 (0.48) | ALDH1A1GAAMAPTCYP1A2CYP3A4 | |
| SCHEMBL8886313 | 0.73 | CYP1A2 (0.43) | ALDH1A1GAAMAPTRECQLL3MBTL1 | |
| SCHEMBL8290956 | 0.73 | ALDH1A1 (0.67) | SCN9AEGLN1ALDH1A1L3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597916-A | 1 substituted oxindoles and azaoxindoles | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-01-28 | — | — | US | disclosed |
| US-5519132-A | ALZHEIMER*S DISEASE, NERVOUS SYSTEM DISORDERS, PROMOTE RELEASE OF ACETYLCHOLINE | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-05-21 | — | — | US | disclosed |
| US-5428035-A | Enhance the release of neurotransmitter acetylcholine and useful for treating alzheimer's disease and cognition activator | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-06-27 | — | — | US | disclosed |
| WO-1994007891-A1 | 1-SUBSTITUTED OXINDOLES AND AZAOXINDOLES AS NOVEL COGNITION ENHANCERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-04-14 | — | — | WO | disclosed |
| US-5296478-A | 1-substituted oxindoles as cognition enhancers | THE DUPONT MERCK PHARMACEUTICAL CO. (US) | 1994-03-22 | — | — | US | disclosed |