Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL9391496 | 0.99 | KCNQ2 (0.49) | KCNQ2CYP3A4TSHRALOX15ADRA1D | |
| Water SCHEMBL9391493 | 0.99 | KCNQ2 (0.49) | KCNQ2CYP3A4TSHRALOX15ADRA1D | |
| SCHEMBL8873348 | 0.88 | KCNQ2 (0.44) | KCNQ2CYP3A4TSHRALOX15ADRA1D | |
| SCHEMBL8873829 | 0.84 | ALDH1A1 (0.55) | KCNQ2CYP3A4TSHRALOX15ALDH1A1 | |
| SCHEMBL8874321 | 0.81 | ALDH1A1 (0.44) | CYP3A4TSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8874688 | 0.80 | SCN9A (0.41) | CYP3A4ALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9079903 | 0.77 | KCNQ2 (0.46) | KCNQ2CYP3A4TSHRALOX15ADRA1D | |
| SCHEMBL8874241 | 0.76 | ALDH1A1 (0.48) | KCNQ2CYP3A4TSHRALOX15ALDH1A1 | |
| SCHEMBL8873955 | 0.73 | ATM (0.45) | KCNQ2CYP3A4TSHRALOX15ALDH1A1 | |
| SCHEMBL8874306 | 0.73 | KCNQ2 (0.53) | KCNQ2CYP3A4TSHRALOX15ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597916-A | 1 substituted oxindoles and azaoxindoles | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-01-28 | — | — | US | disclosed |
| US-5519132-A | ALZHEIMER*S DISEASE, NERVOUS SYSTEM DISORDERS, PROMOTE RELEASE OF ACETYLCHOLINE | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-05-21 | — | — | US | disclosed |
| US-5428035-A | Enhance the release of neurotransmitter acetylcholine and useful for treating alzheimer's disease and cognition activator | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-06-27 | — | — | US | disclosed |
| WO-1994007891-A1 | 1-SUBSTITUTED OXINDOLES AND AZAOXINDOLES AS NOVEL COGNITION ENHANCERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-04-14 | — | — | WO | disclosed |
| US-5296478-A | 1-substituted oxindoles as cognition enhancers | THE DUPONT MERCK PHARMACEUTICAL CO. (US) | 1994-03-22 | — | — | US | disclosed |