Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8874714 | 1.00 | KMT2A (0.38) | KMT2AHSP90AA1APPPOLBCTDSP1 | |
| SCHEMBL6506348 | 0.92 | KMT2A (0.40) | KMT2AHSP90AA1POLBCTDSP1MAOB | |
| SCHEMBL8874990 | 0.82 | TDP1 (0.36) | KMT2AHSP90AA1POLBCTDSP1MAOB | |
| SCHEMBL8874984 | 0.82 | TDP1 (0.36) | KMT2AHSP90AA1POLBCTDSP1MAOB | |
| SCHEMBL8874976 | 0.82 | TDP1 (0.36) | KMT2AHSP90AA1POLBCTDSP1MAOB | |
| SCHEMBL8875013 | 0.79 | KMT2A (0.33) | KMT2AHSP90AA1POLBCTDSP1MAOB | |
| SCHEMBL8875020 | 0.79 | KMT2A (0.33) | KMT2AHSP90AA1POLBCTDSP1MAOB | |
| SCHEMBL8875016 | 0.79 | KMT2A (0.33) | KMT2AHSP90AA1POLBCTDSP1MAOB | |
| SCHEMBL8177291 | 0.79 | TAAR1 (0.46) | KMT2AHSP90AA1POLBCTDSP1FFAR1 | |
| SCHEMBL6505023 | 0.76 | ALDH1A1 (0.55) | KMT2AMEN1MMP12ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5633373-A | Enantioselective synthesis of antifolates | ELI LILLY AND COMPANY (US) | 1997-05-27 | — | — | US | disclosed |
| EP-0407212-B1 | Enantioselective synthesis of antifolates | LILLY CO ELI (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5516776-A | Enantioselective synthesis of antifolates | ELI LILLY AND COMPANY (US) | 1996-05-14 | — | — | US | disclosed |
| US-5159090-A | Enantioselective synthesis of antifolates | ELI LILLY AND COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| US-5008391-A | Enantioselective synthesis of antifolates | ELI LILLY AND COMPANY (US) | 1991-04-16 | — | — | US | disclosed |
| EP-0407212-A1 | Enantioselective synthesis of antifolates | ELI LILLY AND COMPANY (US) | 1991-01-09 | — | — | EP | disclosed |