SCHEMBL8874741

SCHEMBL8874741

Cc1cc(Cl)c(N)cc1NCCO

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 3/20 0.39
CYP2D6 P10635 2/20 0.39
GAA P10253 4/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
MAPK1 P28482 1/20 0.36
BRD4 O60885 1/20 0.35
CD44 P16070 1/20 0.35
TSHR P16473 2/20 0.34
CYP1A2 P05177 1/20 0.34
POLB P06746 1/20 0.34
TP53 P04637 2/20 0.34
ALDH1A1 P00352 4/20 0.33
KDM4E B2RXH2 3/20 0.33
MAPT P10636 1/20 0.33
GLA P06280 1/20 0.33
HPGD P15428 1/20 0.33
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
CHRM1 P11229 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8873600 0.98 GAA (0.39) CYP2C19CYP2D6GAAMEN1KMT2A
SCHEMBL8874564 0.86 CYP2C19 (0.39) CYP2C19CYP2D6GAAMEN1KMT2A
SCHEMBL9069744 0.84 GAA (0.39) CYP2C19CYP2D6GAAMEN1KMT2A
SCHEMBL6261455 0.77 MEN1 (0.45) CYP2C19GAAMEN1KMT2AMAPK1
SCHEMBL8873875 0.77 BMPR1B (0.39) GAAMEN1KMT2AMAPK1TSHR
SCHEMBL15513377 0.77 MAPK1 (0.43) CYP2C19CYP2D6GAAMEN1KMT2A
SCHEMBL11760633 0.74 ALDH1A1 (0.38) CYP2C19GAAMEN1KMT2AMAPK1
SCHEMBL8874779 0.74 POLB (0.40) CYP2D6GAAMEN1KMT2AMAPK1
SCHEMBL11097962 0.74 CYP2D6 (0.43) CYP2C19CYP2D6GAAKMT2APOLB
SCHEMBL10364119 0.74 RET (0.37) CYP2C19CYP2D6GAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5645610-A COUPLER, DEVELOPER WELLA AKTIENGESELLSCHAFT (DE) 1997-07-08 US claimed
EP-0687669-A1 Hair dyeing compositions and new 2-alkylamino-4-amino-1-alkylbenzenes Wella Aktiengesellschaft (DE) 1995-12-20 EP claimed
US-5645610-A COUPLER, DEVELOPER WELLA AKTIENGESELLSCHAFT (DE) 1997-07-08 US disclosed
US-5645610-A COUPLER, DEVELOPER WELLA AKTIENGESELLSCHAFT (DE) 1997-07-08 US disclosed
EP-0687669-A1 Hair dyeing compositions and new 2-alkylamino-4-amino-1-alkylbenzenes Wella Aktiengesellschaft (DE) 1995-12-20 EP disclosed