Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8873632 | 0.92 | CYP1A2 (0.47) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8873178 | 0.85 | ALDH1A1 (0.46) | OPRM1OPRK1OPRL1L3MBTL1ITGB2 | |
| SCHEMBL9079903 | 0.83 | KCNQ2 (0.46) | PDE4APDE4BPDE4CPDE4DOPRM1 | |
| SCHEMBL8873879 | 0.80 | ALDH1A1 (0.46) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8873140 | 0.75 | ALDH1A1 (0.57) | PDE4APDE4BPDE4CPDE4DL3MBTL1 | |
| SCHEMBL8873348 | 0.73 | KCNQ2 (0.44) | PDE4APDE4BPDE4CPDE4DOPRM1 | |
| SCHEMBL8874434 | 0.73 | ATM (0.47) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8874321 | 0.72 | ALDH1A1 (0.44) | ITGB2ICAM1ITGALALDH1A1CYP1A2 | |
| SCHEMBL8874128 | 0.72 | ALDH1A1 (0.50) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8875512 | 0.68 | ALDH1A1 (0.43) | PDE4APDE4BPDE4CPDE4DOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597916-A | 1 substituted oxindoles and azaoxindoles | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-01-28 | — | — | US | disclosed |
| US-5519132-A | ALZHEIMER*S DISEASE, NERVOUS SYSTEM DISORDERS, PROMOTE RELEASE OF ACETYLCHOLINE | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-05-21 | — | — | US | disclosed |
| US-5428035-A | Enhance the release of neurotransmitter acetylcholine and useful for treating alzheimer's disease and cognition activator | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-06-27 | — | — | US | disclosed |
| WO-1994007891-A1 | 1-SUBSTITUTED OXINDOLES AND AZAOXINDOLES AS NOVEL COGNITION ENHANCERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-04-14 | — | — | WO | disclosed |
| US-5296478-A | 1-substituted oxindoles as cognition enhancers | THE DUPONT MERCK PHARMACEUTICAL CO. (US) | 1994-03-22 | — | — | US | disclosed |