Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 3/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.60 |
| ▸ | CYP24A1 | Q07973 | 6/20 | 0.51 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 3/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | CYP27A1 | Q02318 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8596909 | 1.00 | METAP1 (0.65) | METAP1CYP19A1CYP24A1CYP26A1ACHE | |
| SCHEMBL8600912 | 0.89 | METAP1 (0.64) | METAP1CYP19A1CYP24A1CYP26A1ACHE | |
| SCHEMBL8873898 | 0.89 | METAP1 (0.64) | METAP1CYP19A1CYP24A1CYP26A1ACHE | |
| SCHEMBL6272399 | 0.89 | METAP1 (0.65) | METAP1CYP19A1CYP24A1CYP26A1ACHE | |
| SCHEMBL6272211 | 0.85 | METAP1 (0.68) | METAP1CYP19A1CYP24A1CYP26A1ACHE | |
| SCHEMBL9854934 | 0.84 | METAP1 (0.60) | METAP1CYP19A1CYP24A1CYP26A1ACHE | |
| SCHEMBL15617638 | 0.84 | METAP1 (0.70) | METAP1CYP19A1CYP24A1CYP26A1ACHE | |
| SCHEMBL14306761 | 0.82 | METAP1 (0.72) | METAP1CYP19A1CYP24A1CYP26A1ACHE | |
| SCHEMBL6278666 | 0.82 | METAP1 (0.57) | METAP1CYP19A1CYP24A1CYP26A1ACHE | |
| SCHEMBL8874769 | 0.82 | METAP1 (0.69) | METAP1CYP19A1CYP24A1CYP26A1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |