Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 3/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.55 |
| ▸ | PPARG | P37231 | 3/20 | 0.48 |
| ▸ | CYP24A1 | Q07973 | 3/20 | 0.47 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.47 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14061633 | 0.88 | CYP24A1 (0.60) | METAP1CYP19A1CYP24A1CYP26A1CYP27A1 | |
| SCHEMBL6272399 | 0.84 | METAP1 (0.65) | METAP1CYP19A1CYP24A1CYP26A1CYP27A1 | |
| SCHEMBL8596909 | 0.84 | METAP1 (0.65) | METAP1CYP19A1CYP24A1CYP26A1CYP27A1 | |
| SCHEMBL8874844 | 0.84 | METAP1 (0.65) | METAP1CYP19A1CYP24A1CYP26A1CYP27A1 | |
| SCHEMBL6272211 | 0.84 | METAP1 (0.68) | METAP1CYP19A1CYP24A1CYP26A1CYP27A1 | |
| SCHEMBL14306761 | 0.81 | METAP1 (0.72) | METAP1CYP19A1CYP24A1CYP26A1CYP27A1 | |
| SCHEMBL4093483 | 0.81 | HSD17B1 (0.50) | METAP1CYP19A1ACHE | |
| SCHEMBL7737589 | 0.80 | METAP1 (0.52) | METAP1CYP19A1ACHE | |
| SCHEMBL15617638 | 0.80 | METAP1 (0.70) | METAP1CYP19A1CYP24A1CYP26A1CYP27A1 | |
| SCHEMBL4730776 | 0.80 | ALDH1A1 (0.70) | METAP1CYP19A1PPARGCYP24A1CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4983628-A | ANTIASTHMATIC, ANTIALLERGIC, ANTIINFLAMMATORY AND CYTOPROTECTIVE AGENTS | MERCK FROSST CANADA, INC. (CA) | 1991-01-08 | — | — | US | disclosed |
| EP-0140684-B1 | LEUKOTRIENE ANTAGONISTS | MERCK FROSST CANADA INC. (CA) | 1990-07-11 | — | — | EP | disclosed |
| US-4683325-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS | MERCK FROSST CANADA, INC. (CA) | 1987-07-28 | — | — | US | disclosed |
| EP-0140684-A2 | Leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1985-05-08 | — | — | EP | disclosed |