Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 3/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5387687 | 0.81 | SLC6A4 (0.59) | HTR2CADRB2SLC6A4HTR1ASLC6A2 | |
| SCHEMBL4670703 | 0.78 | HTR2C (0.58) | HTR2CADRB2SLC6A4HTR1ASLC6A2 | |
| SCHEMBL26965710 | 0.78 | HTR2C (0.58) | HTR2CADRB2SLC6A4APP | |
| SCHEMBL8877318 | 0.76 | SLC6A4 (0.57) | SLC6A4 | |
| SCHEMBL30228461 | 0.75 | HTR2C (1.00) | HTR2CSLC6A4HTR1ASLC6A2SLC6A3 | |
| SCHEMBL613612 | 0.75 | HTR2C (1.00) | HTR2CSLC6A4HTR1ASLC6A2SLC6A3 | |
| SCHEMBL8879489 | 0.74 | HTR2C (0.54) | HTR2CADRB2SLC6A4APPHTR6 | |
| SCHEMBL8554103 | 0.74 | HTR2C (0.60) | HTR2CADRB2SLC6A4HTR1ASLC6A2 | |
| SCHEMBL2783823 | 0.74 | HTR2C (0.73) | HTR2CSLC6A4HTR1ASLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL30853595 | 0.73 | HTR2C (1.00) | HTR2CSLC6A4HTR1ASLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | disclosed |
| CN-1133840-A | Indolepiperidine derivatives | MERCK PATENT GMBH (DE) | 1996-10-23 | — | — | CN | disclosed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |